Open AccessInfluence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid, and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbo
Author(s) -
Ulrika Carstensen,
SM Hou,
A-K Alexandrie,
Benkt Högstedt,
Christer Tagesson,
Margareta Warholm,
Agneta Rannug,
Bo Lambert,
Anna Axmon,
Lars Hagmar
Publication year - 1999
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.445
Subject(s) - micronucleus test , peripheral blood mononuclear cell , gene , micronucleus , enzyme , dna , biotransformation , chemistry , mutation , biochemistry , genetics , microbiology and biotechnology , biology , toxicity , organic chemistry , in vitro
Airborne exposure to polycyclic aromatic hydrocarbons (PAH) in the potroom of an aluminum reduction plant was studied in relation to genotoxic or mutagenic effects, and the possibility of host genotypes of different metabolizing enzymes modifying associations between PAH exposure and genotoxic or mutagenic response was assessed.