Open AccessNight work and breast cancer estrogen receptor status – results from the German GENICA study
Author(s) -
Sylvia Rabstein,
Beate Pesch,
Dirk Pallapies,
Anne Lotz,
Christina Justenhoven,
Christian Baisch,
Markus Schiffermann,
Simon Haas,
Fischer Hp,
Evelyn Heinze,
Christiane Barbara Pierl,
Hiltrud Brauch,
Ute Hamann,
Ko Y,
T. Brüning
Publication year - 2013
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.3360
Subject(s) - breast cancer , estrogen receptor , oncology , medicine , odds ratio , cancer , shift work , estrogen , confounding , confidence interval , case control study , psychiatry
The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.