Open AccessDisappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat
Author(s) -
Kari Kurppa
Publication year - 1981
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.3116
Subject(s) - carboxyhemoglobin , exponential function , carbon monoxide , mathematics , chemistry , exponential growth , exponential distribution , statistics , mathematical analysis , organic chemistry , catalysis
The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.