Disappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat | Zendy

Kari Kurppa | Zendy

Open Access

Disappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat

Author(s) -

Kari Kurppa

Publication year - 1981

Publication title -

scandinavian journal of work environment and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.621

H-Index - 103

eISSN - 1795-990X

pISSN - 0355-3140

DOI - 10.5271/sjweh.3116

Subject(s) - carboxyhemoglobin , exponential function , carbon monoxide , mathematics , chemistry , exponential growth , exponential distribution , statistics , mathematical analysis , organic chemistry , catalysis

The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.

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