Open AccessBrain and blood lead in acute intoxication.
Author(s) -
H. Savolainen,
Jukka Kilpiö
Publication year - 1977
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2788
Subject(s) - lead acetate , lead (geology) , lead poisoning , blood–brain barrier , medicine , physiology , toxicity , anesthesia , central nervous system , biology , psychiatry , paleontology
Administering lead acetate in drinking water to adult male rats resulted in an elevated lead content in blood and brain during 11 subsequent days. The brain and blood lead contents were proportional to each other although the interdependency changed according to the cumulative dose and equilibration period. The present data indicate that the permeability of the blood-brain barrier towards inorganic lead may be dose-dependent and saturable with high doses of the metal.