Open AccessChromosome changes in workers (smokers and nonsmokers) exposed to automobile fuels and exhaust gases.
Author(s) -
Karl Fredga,
L Davring,
Margareta Sunner,
Bengt Olle Bengtsson,
Carl Gustaf Elinder,
P Sigtryggsson,
Maths Berlin
Publication year - 1982
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2482
Subject(s) - sister chromatids , diesel fuel , truck , sister chromatid exchange , chromosome , environmental health , medicine , toxicology , physiology , genetics , demography , automotive engineering , biology , gene , engineering , in vitro , sociology
The incidence of chromosome changes in men occupationally exposed to automobile fuels and exhaust gases was investigated. Blood samples were taken from the following four groups of 12 men: drivers of diesel-engine trucks, drivers of gasoline-engine trucks, automobile inspectors, and a reference group. The men in the groups were matched with respect to age, smoking habits, and length of time in their respective jobs. Chromosome preparations from lymphocytes were made and analyzed by standardized routine methods, and the frequencies of gaps, breaks, and sister chromatid exchanges were recorded. Statistical analysis of the results gave no evidence for a marked occupational effect, though there remains a grave suspicion that working with diesel motors may cause an increased level of chromosome changes. Smokers showed a significant or near significant increase in breaks, total aberrations, and sister chromatid exchanges over the nonsmokers in three of the groups. An analysis of the data revealed a weak positive correlation between the frequencies of chromosome breaks and sister chromatid exchanges in an individual.