Open AccessIncreased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.
Author(s) -
Benkt Högstedt,
Bengt Åkesson,
K Axell,
Bo Gullberg,
Felix Mitelman,
Ronald W. Pero,
Staffan Skerfving,
Hans Welinder
Publication year - 1983
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2414
Subject(s) - micronucleus test , styrene , mandelic acid , micronucleus , polyester , creatinine , unsaturated polyester , lymphocyte , chemistry , materials science , nuclear chemistry , toxicology , medicine , immunology , composite material , biology , copolymer , polymer , biochemistry , toxicity , organic chemistry
A new micronucleus method based on the analysis of lymphocytes with preserved cytoplasm revealed an increased frequency of micronuclei in 38 workers employed in a plant producing styrene-modified polyester resin as compared to the frequency in 20 referents (5.9 vs 3.6%). The time-weighted average of the styrene concentration in the workroom air varied between 1 and 36 ppm (mean 13 ppm) during the last year and correlated well to low urinary levels of mandelic acid, which ranged from 9 to 316 mg/g of creatinine (mean 65 mg/g of creatinine).