Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene. | Zendy

Benkt Högstedt | Zendy; Benny Åkesson | Zendy; K Axell | Zendy; Bo Gullberg | Zendy; Felix Mitelman | Zendy; R W Pero | Zendy; Staffan Skerfving | Zendy; Hans Welinder | Zendy

Open Access

Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.

Author(s) -

Benkt Högstedt,

Benny Åkesson,

K Axell,

Bo Gullberg,

Felix Mitelman,

R W Pero,

Staffan Skerfving,

Hans Welinder

Publication year - 1983

Publication title -

scandinavian journal of work environment and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.621

H-Index - 103

eISSN - 1795-990X

pISSN - 0355-3140

DOI - 10.5271/sjweh.2414

Subject(s) - micronucleus test , styrene , mandelic acid , micronucleus , polyester , creatinine , unsaturated polyester , lymphocyte , chemistry , materials science , nuclear chemistry , toxicology , medicine , immunology , composite material , biology , copolymer , polymer , biochemistry , toxicity , organic chemistry

A new micronucleus method based on the analysis of lymphocytes with preserved cytoplasm revealed an increased frequency of micronuclei in 38 workers employed in a plant producing styrene-modified polyester resin as compared to the frequency in 20 referents (5.9 vs 3.6%). The time-weighted average of the styrene concentration in the workroom air varied between 1 and 36 ppm (mean 13 ppm) during the last year and correlated well to low urinary levels of mandelic acid, which ranged from 9 to 316 mg/g of creatinine (mean 65 mg/g of creatinine).

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