Biological half-time of cadmium in the blood of workers after cessation of exposure. | Zendy

Lars Järup | Zendy; Artur Rogenfelt | Zendy; C G Elinder | Zendy; Kōji Nogawa | Zendy; Tord Kjellström | Zendy

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Biological half-time of cadmium in the blood of workers after cessation of exposure.

Author(s) -

Lars Järup,

Artur Rogenfelt,

C G Elinder,

Kōji Nogawa,

Tord Kjellström

Publication year - 1983

Publication title -

scandinavian journal of work environment and health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.621

H-Index - 103

eISSN - 1795-990X

pISSN - 0355-3140

DOI - 10.5271/sjweh.2404

Subject(s) - cadmium , compartment (ship) , internal dose , blood component , physiology , blood concentration , component (thermodynamics) , toxicokinetics , toxicology , medicine , chemistry , biology , pharmacokinetics , emergency medicine , radiochemistry , physics , thermodynamics , oceanography , organic chemistry , geology

The biological half-time of cadmium in the blood of previously exposed workers was estimated after the cessation of exposure. Five men were followed for a period of 10 to 13 years. One-compartment and two-compartment exponential elimination models were used to describe the decrease in blood cadmium levels over time. The best fit to the observed data was obtained with a two-compartment model. The half-times estimated from this model ranged from 75 to 128 d for the fast component and from 7.4 to 16.0 years for the slow component. The results confirm that there is a very long whole-body biological half-time for cadmium, and the estimated half-times are similar to those obtained with different methods.

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