Open AccessBiological half-time of cadmium in the blood of workers after cessation of exposure.
Author(s) -
Lars Järup,
Artur Rogenfelt,
Carl Gustaf Elinder,
Kôji Nogawa,
Tord Kjellström
Publication year - 1983
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2404
Subject(s) - cadmium , compartment (ship) , internal dose , blood component , physiology , blood concentration , component (thermodynamics) , toxicokinetics , toxicology , medicine , chemistry , biology , pharmacokinetics , emergency medicine , radiochemistry , physics , thermodynamics , oceanography , organic chemistry , geology
The biological half-time of cadmium in the blood of previously exposed workers was estimated after the cessation of exposure. Five men were followed for a period of 10 to 13 years. One-compartment and two-compartment exponential elimination models were used to describe the decrease in blood cadmium levels over time. The best fit to the observed data was obtained with a two-compartment model. The half-times estimated from this model ranged from 75 to 128 d for the fast component and from 7.4 to 16.0 years for the slow component. The results confirm that there is a very long whole-body biological half-time for cadmium, and the estimated half-times are similar to those obtained with different methods.