Open AccessChronic effects of trichloroethylene upon S-100 protein content and lipid composition in gerbil cerebellum.
Author(s) -
Titus Kyrklund,
G Goracci,
Kenneth G. Haglid,
Lars Rosengren,
G Porcellati,
Per Kjellstrand
Publication year - 1984
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2353
Subject(s) - gerbil , chemistry , cerebellum , fatty acid , phosphatidylethanolamine , phospholipid , biochemistry , hippocampus , myelin , medicine , endocrinology , biology , central nervous system , phosphatidylcholine , ischemia , membrane
Gerbil rats were exposed to trichloroethylene (TCE) vapors intermittently (8 h/d) at 510 ppm or continuously at 170 ppm for five months. The cerebellar content of S-100 protein and the phospholipid fatty-acid profiles were determined. S-100 protein, a possible marker for astrocytic reactivity, indicated delayed astrocytic reactivity in the anterior cerebellar hemisphere and a decrease of S-100 protein in the posterior cerebellar vermis. Minor lipid changes were observed. The fatty-acid profiles of ethanolamine phosphoglycerides showed a tendency towards alterations among the 22-carbon fatty acids, with a decrease in 22:5 (N-3), similar to those shown earlier for cerebral cortex and hippocampus of the gerbil. Two monoenoic fatty acids were decreased, the 20:1 of phosphatidyl-ethanolamine and the 18:1 of the phosphatidyl-serine. This occurrence could indicate a decrease in myelin in areas where these two fatty acids were found to be enriched.