Open AccessAstrogliosis in the cerebral cortex of gerbils after long-term exposure to 1,1,1-trichloroethane.
Author(s) -
Lars Rosengren,
A Aurell,
Per Kjellstrand,
Kenneth G. Haglid
Publication year - 1985
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2201
Subject(s) - astrogliosis , gerbil , neurotoxicity , glial fibrillary acidic protein , cerebral cortex , cortex (anatomy) , endocrinology , chemistry , medicine , biology , neuroscience , toxicity , central nervous system , immunohistochemistry , ischemia
Mongolian gerbils (Meriones ungiculatus) were continuously exposed by inhalation to 1,1,1-trichloroethane at 70, 210, or 1 000 ppm for three months, followed by a four-month postexposure solvent-free period. Concentrations of two astroglial proteins, S-100 and glial fibrillary acidic (GFA) protein, were then determined in different regions of the cerebral cortex. The main biochemical alterations induced after exposure to 210 and 1 000 ppm of 1,1,1-trichloroethane demonstrated a pronounced change in gerbil brain; increased concentrations of GFA protein were found in the cerebral sensorimotor cortex at both these exposure levels, an occurrence indicating astrogliosis in this brain region. These results suggest that 1,1,1-trichloroethane should not be regarded as harmless, particularly regarding neurotoxicity, as previously claimed.