Open AccessChronic effects of dichloromethane on amino acids, glutathione and phosphoethanolamine in gerbil brain.
Author(s) -
Carin Briving,
Anders Hamberger,
Per Kjellstrand,
Lars Rosengren,
Je Karlsson,
Kenneth G. Haglid
Publication year - 1986
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.2155
Subject(s) - cerebellum , glutamine , glutathione , dichloromethane , gerbil , glutamate receptor , cerebral cortex , medicine , chemistry , endocrinology , amino acid , biochemistry , biology , receptor , ischemia , solvent , enzyme
Mongolian gerbils were exposed to dichloromethane for three months by continuous inhalation at 210 ppm. Total free tissue amino acids, glutathione, and phosphoethanolamine were determined in the vermis posterior of the cerebellum and the frontal cerebral cortex. These two brain areas were chosen because humans occupationally exposed to dichloromethane have shown abnormalities in the electroencephalogram of the frontal part of the cerebral cortex. This study showed that long-term exposure of gerbils to dichloromethane (210 ppm) for three months leads to decreased levels of glutamate, gamma-aminobutyric acid, and phosphoethanolamine in the frontal cerebral cortex, while glutamine and gamma-aminobutyric acid are elevated in the posterior cerebellar vermis.