Open AccessBiosafety considerations in industries with production methods based on the use of recombinant deoxyribonucleic acid.
Author(s) -
Lars Andrup,
Birgitte H Nielsen,
Steen Kølvraa
Publication year - 1990
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.1812
Subject(s) - biosafety , recombinant dna , production (economics) , biology , microbiology and biotechnology , genetically modified organism , bacteria , genetically engineered , biochemical engineering , genetics , gene , engineering , macroeconomics , economics
Since no occupational accidents or diseases have been attributed specifically to the use of constructions containing recombinant deoxyribonucleic acid (rDNA), this paper evaluates the occupational health risks in industries utilizing genetically manipulated organisms mainly on the basis of theoretical considerations. Bacteria, filamentous fungi, yeasts, and mammalian cells in culture are in use. For each of these systems the possible hazards are considered. Concerning microbial production systems, infections are regarded as the main problem, but the risk of infection is considered extremely low. As for cells in culture, only dormant viruses are regarded as problematic, but well-defined production cell lines should not contain such undetected and dangerous viruses. Overall, the additional risks posed by rDNA-modified micro-organisms are minor. Only long-term observations can, however, confirm this assumption, and consequently the highest feasible containment measures should still be used in the years to come.