Open AccessCerebrospinal fluid proteins in men with chronic encephalopathy after exposure to organic solvents.
Author(s) -
Lars Barregård,
Carsten Wikkelsö,
Lars Rosengren,
A Aurell,
G Thiringer,
L Nilson,
Gerd Sällsten,
Kenneth G. Haglid,
Christian Blomstrand
Publication year - 1990
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.1765
Subject(s) - cerebrospinal fluid , haptoglobin , albumin , transthyretin , encephalopathy , glial fibrillary acidic protein , chemistry , csf albumin , cerebrospinal fluid proteins , medicine , pathology , biochemistry , immunohistochemistry
Cerebrospinal fluid was examined for 23 patients with chronic toxic encephalopathy after heavy exposure to organic solvents and 23 healthy age-matched referents. No differences were found between the patients and referents with respect to the levels of albumin, immunoglobulin, prealbumin, alpha-1-antitrypsin, beta-2-microglobulin, haptoglobin, or the astroglial cell proteins S100 and glial fibrillary acidic protein in the cerebrospinal fluid. The albumin ratio was normal for both the patients and the referents. The patient group had had heavy exposure to organic solvents, but its members had not been exposed for at least one year before the study. It was concluded that, if exposure to organic solvents affects proteins in cerebrospinal fluid, such effects are probably reversible.