Open AccessA collaborative study of cancer incidence and mortality among vinyl chloride workers.
Author(s) -
Lorenzo Simonato,
Kristan A. L’Abbe,
Aage Andersen,
Stefano Belli,
Pietro Comba,
G Engholm,
Gilles Ferro,
Lars Hagmar,
Sverre Langård,
Ingvar Lundberg
Publication year - 1991
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.1715
Subject(s) - liver cancer , cancer , confidence interval , medicine , incidence (geometry) , lung cancer , international agency , cohort study , standardized mortality ratio , cohort , demography , cancer registry , epidemiology , environmental health , toxicology , oncology , biology , mathematics , geometry , sociology
A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).