Open AccessMortality of employees in plants manufacturing 4,4'-bipyridyl.
Author(s) -
G.M. Paddle,
Amanda Osborn,
G. D. J. Parker
Publication year - 1991
Publication title -
scandinavian journal of work, environment and health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.621
H-Index - 103
eISSN - 1795-990X
pISSN - 0355-3140
DOI - 10.5271/sjweh.1714
Subject(s) - cohort , medicine , lung cancer , incidence (geometry) , hazard ratio , cohort study , environmental health , prospective cohort study , occupational hygiene , hazard , demography , confidence interval , surgery , oncology , pathology , occupational safety and health , biology , physics , sociology , ecology , optics
A historical-prospective cohort study was conducted of 729 male employees of plants manufacturing 4,4'-bipyridyl. The cohort was studied because employment in some of the plants had been linked to malignant and nonmalignant skin lesions attributed to exposure to tarry by-products. The overall mortality experience of the cohort did not show any statistically significant findings. More-detailed analysis of subdivision of the cohort gave results that justified further inquiry into lung cancer incidence. A nested case-referent study did not indicate that any occupational factor other than employment in a bipyridyl plant was related to the incidence of lung cancer. The epidemiologic, toxicologic, and industrial hygiene information was assessed, and it was concluded that there was no evidence of a plausible occupational hazard of lung cancer to the bipyridyl workers, but that a follow-up of the cohort after an interval of five years should be undertaken.