Open AccessHypoglycemic Potential of Combined Methanolic Extract of Seeds of Nigella sativa (Black Cumin) and Cicer Arietinum (Chickpea)
Author(s) -
Muhammad Tahir Akhtar,
Zoha Malik,
Abu Bakar Siddique,
Nargis Sultana,
Muhammad Irfan,
Rahman Qadir,
Suleman Saleem,
Syed Naseer Shah,
Mubshara Saadia
Publication year - 2021
Publication title -
pakistan journal of biochemistry and biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2788-4503
pISSN - 2707-5494
DOI - 10.52700/pjbb.v2i2.55
Subject(s) - nigella sativa , phytochemical , dpph , alloxan , antioxidant , traditional medicine , chemistry , diabetes mellitus , food science , medicine , biochemistry , endocrinology
In spite of the rapid progress in the field of medicine, humanity still striving for cure of diabetes, a disorder of metabolism. From literature study it is inferred that no one therapeutic agent is isolated and/ or synthesized to treat diabetes, but to manage the disease. Therefore, it is of much importance to address this medical issue with phytochemical synergism for boosting immunity and limiting the severe side effects of synthetic hypoglycemic agents. The antioxidant and hypoglycemic effects of black seeds and chickpea have been determined previously, however the combined hypoglycemic effect of these seeds has not been studied until now. In present study the combined methanolic extract (CME) of Nigella sativa (black cumen) and Cicer arietinum (chickpea) seeds has shown the significant antioxidant potential as revealed by its significantly reduced IC50 value for radical scavenging activity in DPPH assay (-36.39%, p 0.05) increase (2.12%) in observed body weights, however, showed the significant decrease in blood glucose levels (-42.24%, p<0.001) compared to the diabetic control rats. Our findings suggest that CME may be used as a potential hypoglycemic herbal medication or might be used in conjunction with the usual synthetic drugs to boost activity and limit the side effects.