Open AccessPrediction of Human proteins having interactions with HPV16 proteins using virus and host sequence motifs.
Author(s) -
Rabbiah Manzoor Malik,
Sahar Fazal,
Syed Touqeer Abbas,
Aamer Iqbal Bhatti,
Mukhtar Ullah,
Mustafa Arif Kamal
Publication year - 2021
Publication title -
pakistan journal of biochemistry and biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2788-4503
pISSN - 2707-5494
DOI - 10.52700/pjbb.v2i2.54
Subject(s) - proteome , biology , human proteome project , human proteins , cervical cancer , dna binding protein , computational biology , human genome , oncogene proteins , virus , peptide sequence , gene , genome , genetics , cancer , proteomics , regulation of gene expression , transcription factor
Background: Human Papillomavirus (HPV) infection has been found to be the major cause of cancer of cervical region, in females. Genome of HPV codes for 6 functional proteins E1, E2, E4, E5, E6 and E7. These proteins play different roles in development of HPV infection and its progression towards cervical cancer. The interactions of HPV proteins with human DNA and proteins occurs in the presence of short linear peptide motifs on these proteins, have similar sequence to those found on proteins in human cells.
Methods: After identification of human motifs in HPV proteins, by use of ELM resource, their counter domains were found from PROSITE. The proteins of human proteome containing these counter domains were predicted as the proteins having possibility of interactions with HPV proteins.
Results: we predicted 9468 human proteins for having interactions with HPV proteins. Our predicted proteins were enriched with the host proteins having possibility of being interacted by HPV proteins. 10% of our predicted proteins were already reported to be affected by one or more HPV proteins. The list of predicated proteins can be utilized to find out the connectivity between the virus HPV and human host. It can also be used to determine the pathways involved in pathogenesis of HPV leading towards the cervical cancer
Conclusion: The list of predicated proteins can be utilized to find out the connectivity between the virus HPV and human host. It can also be used to determine the pathways involved in pathogenesis of HPV leading towards the cervical cancer.