Open AccessA Synthesis and Pharmaceutical Evaluation of Pyrimidine Derivatives and Their Docking Studies
Author(s) -
Nusrat Shafiq,
Azhar Rasul,
Sonia Ashraf,
Shahida Parveen,
Sania Zafar Iqbal,
KiHyun Kim,
Rashid Ali Khan,
Bakhat Ali,
Farhat Jabeen,
Sadia Naureen
Publication year - 2020
Publication title -
frontiers in chemical sciences
Language(s) - English
Resource type - Journals
eISSN - 2709-9954
pISSN - 2707-6024
DOI - 10.52700/fcs.v1i2.9
Subject(s) - carboxylate , pyrimidine , chemistry , docking (animal) , yield (engineering) , antifungal , stereochemistry , proton nmr , combinatorial chemistry , biology , materials science , medicine , nursing , microbiology and biotechnology , metallurgy
A series of halogenated pyrimidine derivatives tetrahydropyrimidine; Ethyl-6-methyl2-oxo-4-phenyl-1,3,4-tetrahydropyrimidine-5-carboxylate (10a), Ethyl-4-(3-Chlorophenyl)-6-methyl-2-oxo-1,3,4-tetrahydropyrimidine-5- carboxylate (10b) andEthyl-4-(4-Chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (10c) were synthesized by using new strategy in “Grindstone protocol “toget high yield in short time. The synthesized compounds werecharacterized by 1HNMR, 13C-NMR and Mass spectral data and evaluated for their anticanceractivityagainsthuman HepG2 Liver cell lines, for antifungal and insecticidal activities.All the synthesized compounds (10a-c) were studied to measure the interactions bydocking study.