Open AccessAnti MRSA and Antiviral Evaluation of Nano Silver Against Avian Influenza virus
Author(s) -
Muhammad Sannan Ahmad,
Hira Musaddiq,
Mirza Imran Shahzad
Publication year - 2020
Publication title -
frontiers in chemical sciences
Language(s) - English
Resource type - Journals
eISSN - 2709-9954
pISSN - 2707-6024
DOI - 10.52700/fcs.v1i2.11
Subject(s) - embryonated , staphylococcus aureus , influenza a virus subtype h5n1 , virus , methicillin resistant staphylococcus aureus , chemistry , microbiology and biotechnology , virology , biology , bacteria , genetics
Preparation of nano sized silver particles was performed by using flower extract of Aerva javanica (AJ). Conversion of Ag+ ions to nanoscaled Ago was carried out in 90 min reaction by green approach. Antiviral potential of nanosilver (NS) was evaluated against Avian Influenza Virus (AIV) strain H9N2, in 9-11 days old chicken embryonated eggs. Synthesized particles were also screened against four methicillin-resistant Staphylococcus aureus (MRSA) strains by well diffusion method. Formation of spherical particles was confirmed by SPR band at 428 nm. XRD analysis confirmed face centred cubic crystal structure of particles with average particle size of 15 nm as calculated by Debye–Scherrer’s formula. Remarkable anti AIV activity was observed from NS particles with IC50 value 50 ?g/ml and this value is 200 times greater control drug i.e., Amantadine. Synthesized particles were also screened against four methicillin-resistant Staphylococcus aureus (MRSA) strains by well diffusion method. Significantly high antiviral and antibacterial activities were observed from nanosilver particles against AIV H9N2 and all four MRSA strains.Keywords: