Open AccessThiazolidines; The Potential Antimicrobial Agents Against Methicillin-Resistant Strains of Staphylococcus aureus
Author(s) -
Mehwish Tanveer,
Hira Musaddiq,
Atia Iqbal,
Saima Saleem,
Sadia Sagar Iqbal,
Bakhat Ali,
Kiran Mustafa,
Sara Musaddiq
Publication year - 2020
Publication title -
frontiers in chemical sciences
Language(s) - English
Resource type - Journals
eISSN - 2709-9954
pISSN - 2707-6024
DOI - 10.52700/fcs.v1i1.3
Subject(s) - staphylococcus aureus , microbiology and biotechnology , antimicrobial , bacillus subtilis , thiazolidine , klebsiella pneumoniae , antibacterial activity , chemistry , pseudomonas aeruginosa , bacteria , biology , escherichia coli , stereochemistry , biochemistry , genetics , gene
2-Substituted 1,3-Thiazolidine-4-Carboxylic Acids (1-11) were synthesized and screened for their anti-methicillin-resistant Staphylococcus aureus (MRSA) potential. The synthesized compounds were evaluated for their antibacterial activities against four MRSA strains MRSA I, VI, VII and VIII with accession numbers KU662352, KR862285, KR862291 and KU662354 respectively by well diffusion method. In addition, antibacterial evaluations were also performed for gram positive strain Bacillus subtilis and gram-negative strains klebsiella pneumoniae and pseudomonas aeruginosa using same method. Most of the synthesized thiazolidine-4-carboxylic acid derivatives exhibited better antibacterial activities against studied bacterial strains. Amongst the synthesized compounds, 8-10 were found to possess significant activity (Zone in mm) against methicillin-resistant Staphylococcus aureus in addition to the other studied bacterial strains.