Open AccessLiver transplantation in acute liver failure: a challenging scenario
Author(s) -
V Pîrvu,
Angela Peltec,
Adrian Hotineanu
Publication year - 2022
Publication title -
buletinul academiei de ştiinţe a moldovei: ştiinţe medicale
Language(s) - English
Resource type - Journals
ISSN - 1857-0011
DOI - 10.52692/1857-0011.2021.3-71.40
Subject(s) - liver transplantation , medicine , hepatic encephalopathy , encephalopathy , coagulopathy , etiology , liver failure , intensive care medicine , jaundice , transplantation , population , gastroenterology , cirrhosis , environmental health
Acute liver failure is a critical medical condition defined as rapid development of hepatic dysfunction associated with encephalopathy. The prognosis in these patients is highly variable and depends on the etiology, interval between jaundice and encephalopathy, age, and the degree of coagulopathy. Determining the prognosis for this population is vital. Unfortunately, prognostic models with both high sensitivity and specificity for prediction of death have not been developed. Liver transplantation has dramatically improved survival in patients with acute liver failure. Still, 25% to 45% of patients will survive with medical treatment. The identification of patients who will eventually require liver transplantation should be carefully addressed through the combination of current prognostic models and continuous medical assessment.