Open AccessEvaluation of the antifungal and antibacterial action of a new unsaturated 1,2,4-triazole derivative (Nitrotriazon)
Author(s) -
Drumea Maria,
Eugenia Stingaci,
Livia Uncu,
Valeriu Crudu,
Vladimir Valica,
Fliur Macaev
Publication year - 2021
Publication title -
buletinul academiei de ştiinţe a moldovei: ştiinţe medicale
Language(s) - English
Resource type - Journals
ISSN - 1857-0011
DOI - 10.52692/1857-0011.2021.1-69.19
Subject(s) - bifonazole , pharmacophore , antimycobacterial , antimicrobial , chemistry , ketoconazole , triazole , minimum inhibitory concentration , combinatorial chemistry , moiety , antifungal , mycobacterium tuberculosis , stereochemistry , microbiology and biotechnology , tuberculosis , biology , organic chemistry , medicine , pathology
The growing clinical importance of drug-resistant fungal and bacterial pathogens has given additional urgency to microbiological research and the development of new antimicrobial compounds. 1,2,4-Triazoles act as important pharmacophores by interacting with high affinity biological receptors due to their dipole character, hydrogen binding capacity, stiffness and solubility. Following the evaluation of the antifungal activity, Nitrotriazon has MIC/MFC values: from 0.07 to 0.19 mM compared to the reference drugs: Ketoconazole, Bifonazole. Nitrotriazone also showed good antibacterial activity with MIC / MBC values from 0.0006 to 0.0013 mM, compared to the reference drugs Ampicillin and Chloramphenicol. The antimycobacterial activity of Nitrotriazone against M. tuberculosis, the reference strain (H37Rw) and the extended resistance of M. tuberculosis (M/XDR) were also studied.