Open AccessSulfonyl thiosemicarbazones: synthesis, characterization and antibacterial activity
Author(s) -
Priyanka Yadav,
P. Sampath Kumar,
Ayaz Mahmood Dar
Publication year - 2021
Publication title -
the applied biology and chemistry journal
Language(s) - English
Resource type - Journals
ISSN - 2582-8789
DOI - 10.52679/tabcj.2021.0005
Subject(s) - sulfonyl , antibacterial activity , chemistry , strain (injury) , carbon 13 nmr , proton nmr , stereochemistry , nuclear chemistry , organic chemistry , bacteria , biology , alkyl , anatomy , genetics
The reaction of sulfonyl ketones (1-3) with thiosemicarbazide under reflux conditions yielded the sulfonyl thiosemicarbazones (4-6) in good to potential amounts (72-80%). The structure of new compounds (4-6) was confirmed by different spectral (IR, 1H NMR, 13C NMR, MS) and analytical techniques. The investigation of antibacterial screening data revealed that all the tested compounds (4-6) exhibited moderate to decent antibacterial activity against S. pyogenes, S. aureus and E. coli strains. The compounds 4-6 depicted zones of inhibition, i.e., 20.3 mm, 21.2 mm and 19.6 mm against S. pyogenes strain, respectively.