Open AccessRelationship between human genetics and susceptibility to COVID-19 infection
Author(s) -
Preetinder Kaur,
Pawanjot Kaur
Publication year - 2020
Publication title -
the applied biology and chemistry journal
Language(s) - English
Resource type - Journals
ISSN - 2582-8789
DOI - 10.52679/tabcj.2020.0007
Subject(s) - abo blood group system , outbreak , pandemic , human leukocyte antigen , biology , covid-19 , immunology , virology , genetics , medicine , disease , infectious disease (medical specialty) , antigen
Recent studies have shown that the progression of SARS-CoV-2 is associated with human genetic factors. Many patients have shown diverse clinical symptoms based on their age, sex, ABO blood type, underlying medical conditions, HLA system, and viral variants found in their samples. SARS-CoV-2 is considered more transmissible with higher morbidity rates as compared to the previous SARS outbreak. Several case studies have supported the direct relation of cardiovascular and pulmonary fatalities related to ACE2 polymorphisms during COVID-19 infection. SARS-CoV-2 mutants and human genome polymorphisms are vital predictive markers in finding a cure for this pandemic. This review focuses on some of the critical genetic factors of the host that affect the array of immunological responses as a result of COVID-19 infection among individuals.