Open AccessRole of acidic tumor microenvironment in tumor pathogenesis and targeting
Author(s) -
Vishal Sharma,
Chhaya Bawa,
Kuldeep Chand Vatsyan
Publication year - 2020
Publication title -
the applied biology and chemistry journal
Language(s) - English
Resource type - Journals
ISSN - 2582-8789
DOI - 10.52679/tabcj.2020.0005
Subject(s) - tumor microenvironment , angiogenesis , cancer , cancer research , immune system , pathogenesis , cancer cell , tumor cells , biology , tumor progression , immunology , medicine , genetics
Extensive efforts are going on to understand the molecular mechanisms behind tumor initiation, progression, and invasion and find novel targets for cancer treatment. The physiological state of the tumor microenvironment (TME) is crucial to every step of tumor cell growth and angiogenesis. Cancer cells are rarely in contact with each other. The intervening medium between the cancer cells, immune cells, and other cells become acidic, which significantly affects cancer pathogenesis. It could be a novel targeting marker and may help treat tumors. Even after extensive research in this area, the nature of molecular alterations and the basic mechanisms in the tumor microenvironment remains unclear. Based on recent studies of TME, this mini-review bids a more inclusive overview of the role of TME in cancer cell growth. Also, it helps to understand the potential of TME for therapeutic interventions.