Open AccessSynthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
Author(s) -
Iryna Myrko,
Taras Chaban,
V. S. Matiychuk
Publication year - 2022
Publication title -
current chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 5
eISSN - 1927-7296
pISSN - 1927-730X
DOI - 10.5267/j.ccl.2021.9.003
Subject(s) - antimicrobial , chemistry , staphylococcus aureus , candida albicans , cryptococcus neoformans , acinetobacter baumannii , klebsiella pneumoniae , pseudomonas aeruginosa , escherichia coli , microbiology and biotechnology , klebsiella pneumonia , bacteria , organic chemistry , biology , biochemistry , genetics , gene
A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.