Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives | Zendy

T. T. Toshmurodov | Zendy; A. A. Ziyaev | Zendy; С. А. Сасмаков | Zendy; Jaloliddin Abdurakhmanov | Zendy; Мavluda Ziyaeva | Zendy; Д. С. Исмаилова | Zendy; Shakhnoza S. Azimova | Zendy

Open Access

Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives

Author(s) -

T. T. Toshmurodov,

A. A. Ziyaev,

С. А. Сасмаков,

Jaloliddin Abdurakhmanov,

Мavluda Ziyaeva,

Д. С. Исмаилова,

Shakhnoza S. Azimova

Publication year - 2021

Publication title -

current chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.196

H-Index - 5

eISSN - 1927-7296

pISSN - 1927-730X

DOI - 10.5267/j.ccl.2021.5.002

Subject(s) - chemistry , morpholine , antimicrobial , bacillus subtilis , moiety , staphylococcus aureus , antibacterial activity , escherichia coli , bacteria , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , genetics , gene , biology

Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm).

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