Open AccessAmidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives
Author(s) -
Turdibek T. Toshmurodov,
A. A. Ziyaev,
С. А. Сасмаков,
Jaloliddin Abdurakhmanov,
Mavluda Ziyaeva,
Д. С. Исмаилова,
S. I. Azimova
Publication year - 2021
Publication title -
current chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 5
eISSN - 1927-7296
pISSN - 1927-730X
DOI - 10.5267/j.ccl.2021.5.002
Subject(s) - chemistry , morpholine , antimicrobial , bacillus subtilis , moiety , staphylococcus aureus , escherichia coli , cytisine , antibacterial activity , bacteria , stereochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry , receptor , biology , gene , genetics , nicotinic agonist
Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm).