Open AccessSynthesis and spectral characterization of selective pyridine compounds as bioactive agents
Author(s) -
Shaban A. A. Abdel-Raheem,
Adel M. Kamal ElDean,
Reda Hassanien,
Mohamed E. A. El-Sayed,
Mostafa Sayed,
Aly A. Abd-Ella
Publication year - 2021
Publication title -
current chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 5
eISSN - 1927-7296
pISSN - 1927-730X
DOI - 10.5267/j.ccl.2021.2.001
Subject(s) - chemistry , aphis craccivora , pyridine , sodium ethoxide , aphid , acetamide , acetamiprid , thio , stereochemistry , organic chemistry , medicinal chemistry , aphididae , imidacloprid , pesticide , botany , homoptera , ethanol , agronomy , pest analysis , biology
Starting from 3-cyano-4,6-distyrylpyridin-2(1H)-thione (1), the compound N-(4-chlorophenyl)-2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)acetamide (2) was prepared. Compound (2) underwent cyclization upon heating in ethanolic sodium ethoxide solution to give the corresponding cyclized form 3-amino-N-(4-chlorophenyl)-4,6-distyrylthieno[2,3-b]pyridine-2-carboxamide (3). The elemental analyses and spectroscopic data of compounds (2) and (3) are in agreement with their proposed structures. Their insecticidal activity against cowpea aphid, Aphis craccivora Koch, was studied. The results of insecticidal activity for compounds (2) and (3) against the nymphs and the adults of the tested insects exhibited that compounds (2) and (3) have a higher insecticidal activity than that of acetamiprid, a reference insecticide, after 24 h of treatment.