Open AccessFeCl3/SiO2 NPs as a robust and efficient catalyst for the synthesis of 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones
Author(s) -
Esmaeil Afkhami,
Javad SafaeiGhomi
Publication year - 2016
Publication title -
current chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 5
eISSN - 1927-7296
pISSN - 1927-730X
DOI - 10.5267/j.ccl.2016.7.002
Subject(s) - chemistry , pyrazolones , catalysis , aryl , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
A four-component reaction of phenylhydrazines, ethyl acetoacetate, aldehydes and β-naphthol has been achieved in the presence of FeCl3/SiO2 nanoparticles as a highly effective heterogeneous catalyst to produce 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in good to excellent yields, short reaction times, mild reaction conditions and the employment of a cost-effective catalyst