Open AccessCalcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction
Author(s) -
Muhammad Mansyur Romi,
Nur Arefian,
Wiwit Ananda Wahyu Setyaningsih,
Rachma Greta Perdana Putri,
Mohammad Juffrie,
Dwi Cahyani Ratna Sari
Publication year - 2021
Publication title -
iranian biomedical journal.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.519
H-Index - 31
eISSN - 2008-823X
pISSN - 1028-852X
DOI - 10.52547/ibj.25.6.417
Subject(s) - downregulation and upregulation , uric acid , fibrosis , calcitriol , superoxide dismutase , kidney , dismutase , medicine , chemistry , endocrinology , biochemistry , oxidative stress , vitamin d and neurology , gene
Hyperuricemia induces nephropathy through the mediation of oxidative stress, tubular injury, inflammation, and fibrosis. The high uric acid level is associated with the reduction of vitamin D levels. However, the reno-protective effects of this vitamin in hyperuricemia condition remain unknown. This study aimed to elucidate calcitriol treatment in a uric acid-induced hyperuricemia mice model.