Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction | Zendy

Muhammad Mansyur Romi | Zendy; Nur Arfian | Zendy; Wiwit Ananda Wahyu Setyaningsih | Zendy; Rachma Greta Perdana Putri | Zendy; Mohammad Juffrie | Zendy; Dwi Cahyani Ratna Sari | Zendy

Open Access

Calcitriol Treatment Attenuates Uric Acid-Induced Kidney Injury via Super Oxide Dismutase-1 (SOD-1) Upregulation and Fibrosis Reduction

Author(s) -

Muhammad Mansyur Romi,

Nur Arfian,

Wiwit Ananda Wahyu Setyaningsih,

Rachma Greta Perdana Putri,

Mohammad Juffrie,

Dwi Cahyani Ratna Sari

Publication year - 2021

Publication title -

iranian biomedical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.519

H-Index - 31

eISSN - 2008-823X

pISSN - 1028-852X

DOI - 10.52547/ibj.25.6.417

Subject(s) - downregulation and upregulation , uric acid , calcitriol , fibrosis , kidney , superoxide dismutase , chemistry , medicine , biochemistry , antioxidant , vitamin d and neurology , gene

Hyperuricemia induces nephropathy through the mediation of oxidative stress, tubular injury, inflammation, and fibrosis. The high uric acid level is associated with the reduction of vitamin D levels. However, the reno-protective effects of this vitamin in hyperuricemia condition remain unknown. This study aimed to elucidate calcitriol treatment in a uric acid-induced hyperuricemia mice model.

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