Open AccessEvaluation of Outer Membrane Vesicles Obtained from Predominant Local Isolate of Bordetella pertussis as a Vaccine Candidate
Author(s) -
Maryam Sadat Soltani,
Mojtaba Noofeli,
Seyed Reza Banihashemi,
Fereshteh Shahcheraghi,
Fereshteh Eftekhar
Publication year - 2021
Publication title -
iranian biomedical journal.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.519
H-Index - 31
eISSN - 2008-823X
pISSN - 1028-852X
DOI - 10.52547/ibj.25.6.399
Subject(s) - bordetella pertussis , bacterial outer membrane , vesicle , microbiology and biotechnology , biology , membrane , bacteria , biochemistry , gene , genetics , escherichia coli
Pertussis is a current contagious bacterial disease caused by Bordetella pertussis (Bp). Given the prevalence of pertussis, development of new vaccines is important. This study was attempted to evaluate the expression of main virulence factors (pertussis toxin [PTX], PRN [pertactin], and filamentous hemagglutinin [FHA]) from Bp predominant strains and also compare the expression of these factors in the outer membrane vesicles (OMVs) obtained from predominant circulating Bp isolate.