Open AccessProduction of an Antibody Fragment (scFv) Targeting PcrV Protein of Pseudomonas aeruginosa in Fed-Batch Cultivation Mode
Author(s) -
Saba Karam,
Mozhgan Raigani,
Sahar Hassani Afshar,
Yeganeh Talebkhan,
Elham Bayat,
Samira Komijani,
Leila Nematollahi,
Farzaneh Barkhordari,
Mehdi Shafiee Ardestani,
Fatemeh Davami
Publication year - 2021
Publication title -
iranian biomedical journal.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.519
H-Index - 31
eISSN - 2008-823X
pISSN - 1028-852X
DOI - 10.52547/ibj.25.6.390
Subject(s) - pseudomonas aeruginosa , recombinant dna , lysis , escherichia coli , microbiology and biotechnology , single chain variable fragment , chemistry , antibody , gene , biology , bacteria , biochemistry , immunology , genetics
Pseudomonas aeruginosa is one of the opportunistic pathogens causing frequent hospital-acquired life-threatening infections in mechanically ventilated patients. The most significant virulence factor of P. aeruginosa is type III secretion system (T3SS). PcrV is an important structural protein of the T3SS.