Study of the effectiveness of the use of the drug "Protostop" in diarrhea of bacterial etiology in calves

In the cattle farm, the effect of the use of the drug "Protostop" on the gut microbiota and the welfare of calves with diarrhea of bacterial origin was studied.The drug "Protostop" was administered orally, in doses of 250 mg / kg or 350 mg / kg of weight for three or five days. Samples of feces were collected for bacteriological examination before the use of the drug and 10 days after the end of treatment. At  the same time, the animal welfare, their consumption of water and feed, the presence of changes in the functioning of the gastrointestinal tract, the nature of feces, the condition of mucous membranes and coat were evaluated. The content and species composition of the gut microbiota of calves before and 10 days after the use of the "Protostop" was established by bacteriological methods (inoculation on nutrient media with subsequent counting of grown colonies and identification of cultures).After using the drug, independently of the dose and duration of use, significant improvements in the welfare of the animals were noted: calves became more active, diarrhea was stop, fecal masses became thicker and more homogeneous.Changes in the content and species composition of Enterobacteria of the gut were most significant when using the “Protostop” at a dose of 350 mg / kg of weight for 5 days: 10 days after treatment, there were no strains of hemolytic E.coli and opportunistic microorganisms in the feces.Based on the conducted studies, it was concluded that the drug "Protostop" is effective in the treatment of bacterial diarrhea in calves at a dose of 350 mg / kg of weight for 5 days.