Management of Multisystem Inflammatory Syndrome in Children (MIS-C) Admitted in a Tertiary Care Hospital of North India

Background: Multisystem inflammatory syndrome in children (MIS-C), while being rare and treatable, is the dreadful and mysterious face of the COVID-19 pandemic among children. This study aimed to describe, Management among children admitted as Multisystem Inflammatory Syndrome in Children (MIS-C) in Indira Gandhi Medical College, Shimla in Northern India.Material & Methods: We conducted a cross sectional study of MIS-C from January to July 2021, in pediatric ward of Indira Gandhi Medical College Shimla in Himachal Pradesh. All children admitted with MISC were included. Data regarding socio-demographic factors& management was extracted and analyzed using Epi Info V7 software.Results: In the present study, a total of 31 children admitted as MIS-C were included. Mean age of these patients was 7.12±4.78 years. Among the total 16(51.6%) were males while 15(48.4%) were females. In the present study, 24 (77.4%) patients were given IVIG, among these 22(91.67%) received 2 gm/kg while 2(8.33%) received between 1-2gm/kg.10(32.3%) children received low dose methylprednisolone, 21(67.7%) received, methylprednisolone in high doses. low molecular weight heparin (LoMoH) was given to 17(54.8%) patients. 23 (74.2%) were given Aspirin, among these 21 (91.30%) were given adequate doses, while 2(8.70%) were given between half to full doses of aspirin. Only 1(3.2%) patient had drug reaction and that was fever. Respiratory support was given to 25(80.6%), Oxygen to 18(58.1%), ventilatory support was required by 7(22.6%) and inotropic support was given to 18 (58.1%) children.Conclusion: Besides symptomatic treatment, IVIG, Methylprednisolone, Aspirin, LoMoH, O2, respiratory support and inotropic support were the most important components of management. Comprehensive studies are required to understand the pathogenesis of MIS-C and determine the treatment regimens clearly.Keywords: Management, Multisystem Inflammatory Syndrome in Children (MIS-C), Inotropes, Respiratory support, IVIG