Open AccessThe Relationship of Adiponectin Level with Non-Alcoholic Fatty Liver Disease (NAFLD) Degrees
Author(s) -
Annisa Dwi Andriani,
Gontar Alamsyah Siregar,
Dharma Lindarto
Publication year - 2021
Publication title -
international journal of research and review
Language(s) - English
Resource type - Journals
eISSN - 2454-2237
pISSN - 2349-9788
DOI - 10.52403/ijrr.20210727
Subject(s) - adiponectin , medicine , fatty liver , insulin resistance , gastroenterology , metabolic syndrome , type 2 diabetes , diabetes mellitus , endocrinology , incidence (geometry) , obesity , disease , physics , optics
Background: NAFLD is liver fat that exceeds 5% of the total liver weight. Adiponectin is thought to have a role in the development of insulin resistance and is associated with the incidence of NAFLD. This study aims to find the relationship between adiponectin levels and the degree of NAFLD.Methods: Sixty seven study subjects with metabolic syndrome, went through abdominal ultrasound to diagnose NAFLD and measure BMI, serum adiponectin levels, and NAFLD Fibrosis Score (NFS). The relationship between adiponectin levels, degrees of NAFLD, NFS, and comorbid would be assessed.Results: Forty one (61%) was male and 26 (38.8%) were female with a mean age of 42.08 years. From the abdominal ultrasound, the number of NAFLD grade I, II, and III were 40.4%, 29.8%, 29.8%. The mean adiponectin levels in all samples were 7.13 (3.25-11.45) μg/ml. Both type 2 diabetes and BMI ≥ 23 kg/m2 were associated with the degree of NAFLD (p <0.001). In type 2 diabetes and BMI ≥ 23 kg/m2 group, the mean adiponectin level was found to be lower (p <0.001). The relationship between NFS and NAFLD, also adiponectin levels and the degree of NFS was significant (p <0.001).Conclusion: The relationship between adiponectin levels with the degree of NAFLD and NFS were statistically significant.Keywords: NAFLD, NFS, adiponectin, fibrosis, metabolic syndrome.