Open AccessRelationship between Plasma Vascular Endothelial Growth Factor (VEGF) and Ovarian Cancer Staging
Author(s) -
Erma Wahyuni,
Herman Hariman,
Deri Edianto
Publication year - 2021
Publication title -
international journal of research and review
Language(s) - English
Resource type - Journals
eISSN - 2454-2237
pISSN - 2349-9788
DOI - 10.52403/ijrr.20210714
Subject(s) - ovarian cancer , medicine , vascular endothelial growth factor , angiogenesis , stage (stratigraphy) , cancer , vascular permeability , oncology , vegf receptors , biology , paleontology
Ovarian cancer is the 8th most common cancer that occurs in most women. In a 2018 survey by Global Cancer Statistics in 185 countries of all cancer cases, 3.4% were caused by ovarian cancer. Vascular endothelial growth factor is a multifunctional cytokine that stimulates angiogenesis and increases microvascular permeability by binding to receptors located in endothelial cells in blood vessels. Immature platelet fraction (% IPF) is a modern parameter that measures young platelets and reticulation in peripheral blood. The purpose of this study was to look at differences in plasma VEGF and IPF levels between ovarian cancer sufferers and staging of ovarian cancer. This type of research is a cross sectional observational study of VEGF and Ovarian Cancer stage. A total of 18 people with ovarian cancer were sampled before surgery and after surgery an anatomy pathology examination was performed to assess early stage and advanced cancer staging. From 18 patients with ovarian cancer obtained from the early stage ovarian cancer group and advanced stage group. Obtained a median age of 50 (42-63), whereas in the advanced stage group a median age of 51 (19-68) was obtained. There is a significant difference between VEGF levels in early and advanced stage ovarian cancer with a value of p = 0,000. Using the Spearman Correlation test to assess the correlation between tumor size and VEGF levels, p values <0.001 with r = 0.742 were obtained. The conclusion of this research are advanced stage ovarian cancer VEGF is significantly higher P = 0.001 compared to early stage.Keywords: VEGF, Ovarian Cancer.