Open AccessEstablishment of Reference Values of Gamma-Glutamyl-Transferase and Plasma Aminotransferases in Young Congolese
Author(s) -
Linel Darrel Ngokana,
Fylla Onanga Koumou,
Landry Aymar Loukanou Mbouaka
Publication year - 2021
Publication title -
international journal of health sciences and research
Language(s) - English
Resource type - Journals
ISSN - 2249-9571
DOI - 10.52403/ijhsr.20210939
Subject(s) - reference values , medicine , percentile , alanine aminotransferase , gamma glutamyltransferase , gastroenterology , population , liver enzyme , plasma levels , reference range , endocrinology , enzyme , biochemistry , biology , statistics , mathematics , environmental health
Objectives: Our goal was to contribute to the production of reference values of plasma or serum biochemical markers by determining the reference values of gamma-glutamyltransferase (GGT), aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) in young Congolese presumed to be healthy.Methods: 250 young Congolese presumed to be healthy (125 boys and 125 girls) aged 15 to 25 participated in the study. They were selected according to anamnestic and clinico-biological criteria. Samples were taken on a tube containing EDTA and the resulting plasma was stored at -20 ° C. The KENZA MAX spectrophotometer was used to analyze GGT, ASAT and ALAT. The median and the 2.5-97.5 percentiles were used to set the reference limits for each enzyme. The benchmarks determined were compared with those reported by other Africans, Europeans, Indians and Americans.Results: The established reference values were: GGT 12.15-61.85 IU/L for boys and 7-51.95 IU / l for girls (p˂0.0001); ASAT 21.60-94.85 IU/L for boys and 17-84.85 IU/L for girls (p = 0.0003); ALAT 8.30-74.40 IU/L for boys and 8-53.85 IU/L for girls (p˂0.0001). In addition, the comparison between our values and those of other populations showed significant differences.Conclusion: Our results underline the importance of establishing reference values for plasma enzymes specific to the Congolese population. The use of the values established in the ’other populations could induce errors of judgment by excess or by default.Key words: Gamma-glutamyltransferase, Aspartate aminotransferase, Alanine aminotransferase, Reference values, Congo.