Open AccessAGE AND SEX RELATED CHANGES OF ADIPONECTIN AND GHRELIN IN HEALTHY INDIVIDUALS
Author(s) -
MEDEA JGHARKAVA,
Tinatin Chikovani,
NINO ORJONIKIDZE,
NINO KARANADZE,
Ia Pantsulaia
Publication year - 2022
Publication title -
ek'sperimentuli da klinikuri medic'ina
Language(s) - English
Resource type - Journals
ISSN - 1512-0392
DOI - 10.52340/jecm.2022.03.12
Subject(s) - ghrelin , adiponectin , leptin , resistin , medicine , endocrinology , adipose tissue , obesity , hormone , population , adipokine , insulin resistance , environmental health
Obesity is a global health problem and considered an emerging epidemic of the 21st century. Adipose tissue is an active paracrine gland and secretes many hormone-like substances, including leptin, adiponectin, and resistin, which significantly affect energy balance and metabolism. The aim of our study was to identify possible age-related changes of adiponectin and ghrelin and the risk factors affecting them in a healthy apparently population. The study examined 150 healthy individuals (ages 18-90). Plasma concentrations of adiponectin and ghrelin were determined in each individual using ELISA kits. Based on the study outcomes, adiponectin and ghrelin circulatory levels are associated inversely with weight only in men. Furthermore, age-related changes are also seen in men, whereas in women no statistically reliable connections were detected. Thus, based on the results of the study, it is possible to standardize adiponectin and ghrelin concentrations by gender for each age group.