Open AccessCOMPARATIVE ANALYSIS OF THE SUMS OF ALKALOIDS OF SOME SPECIES OF MAHONIA (FAMILY BERBERIDACEAE), INTRODUCED ON THE TERRITORY OF GEORGIA
Author(s) -
NIKA TODUA,
DAVID CHINCHARADZE,
NINA VACHNADZE
Publication year - 2022
Publication title -
ek'sperimentuli da klinikuri medic'ina
Language(s) - English
Resource type - Journals
ISSN - 1512-0392
DOI - 10.52340/jecm.2022.03.08
Subject(s) - jatrorrhizine , palmatine , berberine , berberidaceae , coptisine , botany , isoquinoline , traditional medicine , alkaloid , chemistry , biology , pharmacology , stereochemistry , medicine
Approaching on comparative phytochemical screening tests of six species of Genus Mahonia Nuttall (Family Berberidaceae), which are introduced on the territory of Georgia, by productivity of biologically active alkaloids our attention deserves: Mahonia aquifolium (Pursh) Nutt., Mahonia bealei (Fort.) Carr; Mahonia japonica (Thunb.) DC.; Mahonia wagneri Join.After studying samples with alkaloids on thin layer chromatography compared with standard solutions, there were identified isoquinoline alkaloids such as: berberine, jatrorrhizine, palmatine, magnoflorine, berbamine and colchicine. The total substance obtained from the vegetative organs of Mahonia aquifolium (Oregon grape) were evaluated for in vitro cytotoxicity against cells of lung carcinoma lines (A-549), colon adenocarcinoma (DLD-1) and normal human fibroblasts (WS-1). As a result, the investigated fractions showed pronounced activity against all cell lines.