Features of the endometrial microenvironment in developing of endometrioid adenocarcinoma

Endometrial Carcinoma is the most common gynaecological malignancy in the female population and is considered as incidentally the second gynaecological malignancy worldwide. Based on 2018 data more than 380 000 new cases were diagnosed worldwide and almost 90 000 of them had a lethal outcome. Interaction between cancer cells and their microenvironment regulates cancer progression in multiple types of cancer. It has great value in developing endometrial cancer and its progression respectively. There is no sufficient research data about the consequences and mechanisms which are participating in endometrial cancer progression and what determines its aggressive behaviour. Molecular signals derived from stromal cells and/or extracellular matrix plays a crucial role in malignancy. The cancer microenvironment is composed of cellular components and noncellular components (extracellular matrix)as well. Cancer cell invasion and metastasizing are some of the leading reasons why endometrial cancer is hardly sensitive to the treatment and has worse overall prognoses. Identification of Signaling pathways of the local microenvironment and peptides synthesized by stromal cells has a critical role in the modification of potentially significant biomarkers for endometrial cancer metastases and high-grade malignancy. In consideration of all of the mentioned microenvironment of endometrial cancer and its single components needs deeper examination while it has a critical value in understanding cancer aetiology, progression and its prognoses.