Open AccessPhenotypic features of the immune microenvironment in ovarian epithelial neoplasms and its role in tumour progression
Author(s) -
Rusudan Devadze,
Arsen Gvenetadze,
George Burkadze
Publication year - 2022
Publication title -
k'art'veli mec'nierebi
Language(s) - English
Resource type - Journals
ISSN - 2667-9760
DOI - 10.52340/gs.2022.04.01.13
Subject(s) - ovarian cancer , immune system , tumor microenvironment , phenotype , ovarian carcinomas , biology , predictive value , infiltration (hvac) , tumor infiltrating lymphocytes , cancer , pathology , cancer research , medicine , ovarian carcinoma , immunology , immunotherapy , gene , biochemistry , physics , thermodynamics
The tumour is characterised by the presence of various amounts of lymphocytic infiltration, which is seen in different areas of cancer and has not only prognostic value the predictive value as well. Tumour-infiltrating lymphocytes (TILs) in ovarian cancer can be associated either with good prognoses or bad prognoses in some cases. The constituent which makes the tumour immune microenvironment is still under vigorous research while they may have the potential to be well modified predictive and prognostic values in ovarian cancer. The data provided by already conducted research are controversial which suggests the need for further deeper studies. Besides this fact, there is no clear determination which histological subtype of ovarian cancer is under research or in many cases all of the morphological types are united. All of these facts mentioned can clarify why the results of many pieces of research provide controversial information. It is crucial that the immune microenvironment of various morphological subtypes of ovarian carcinomas be studied separately and individually.