Open AccessThe Effect Of Halothane On Number Of The Gad65/67 Positive Cells In Rat Hippocampus At The Midazolam Premedication
Author(s) -
Z Vadachkoria,
L Dzidziguri,
Ekaterine Bakuradze,
Irina Modebadze,
Diana Dzidziguri
Publication year - 2021
Language(s) - English
DOI - 10.52340/csw.2021.548
Subject(s) - midazolam , hippocampus , halothane , premedication , anesthesia , hippocampal formation , medicine , sedation
The experimental results of halothane effect on GAD65/67 positive cells, number in ÑÀ1 and ÑÀ1 elds of white rat hippocampus are presented in the proposed work. It has been shown, that the number of GAD65/67 positive cells are decreased in CA3 eld of hippocampus after 24 hours of halothane anesthesia. Simultaneously the number of the same cells are increased in CA1 eld of hippocampus. Midazolam premedication promotes normalization of activity of GAD65/67 which is substantiated by increased number of GAD65/67 positive cells in CA3 eld of rat hippocampus after 24 hours.