Open AccessSYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW PYRAZOLO QUINAZOLINE DERIVATIVES
Author(s) -
Shipra Baluja,
Disha Menpara,
Sumitra Chanda,
Kajal Nandha
Publication year - 2015
Publication title -
latin american applied research
Language(s) - English
Resource type - Journals
eISSN - 1851-8796
pISSN - 0327-0793
DOI - 10.52292/j.laar.2015.391
Subject(s) - antimicrobial , quinazoline , antifungal , chemistry , in vitro , carbon 13 nmr , combinatorial chemistry , proton nmr , gram , bacteria , stereochemistry , biological activity , organic chemistry , microbiology and biotechnology , biochemistry , biology , genetics
Pyrazolo[5,1-b]quinazolines are known to be versatile heterocyclic compounds with different biological properties because of a large number of derivatives with different structural modifications. Therefore, some new Pyrazolo quinazoline heterocycles were synthesized from chalcones and their structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectral data. All these synthesized compounds were tested in vitro for their antimicrobial potential against Gram positive, Gram negative strains of bacteria as well as fungal strains in dimethylsulfoxide. Among the screened compounds, KC-10 showed the most potent antimicrobial activity. None of the compound shows antifungal activity. This may be due to the fact that fungal cells are complex organisms as compared to bacterial cell. Furthermore, the presence of S-CH3 group in the synthesized compounds may cause inactive behavior of these compounds against the studied fungal strains.