Open AccessThe PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity
Author(s) -
Sana Mansoor,
Anshu Maheshwari,
Matthew D. Di Guglielmo,
Katryn N. Furuya,
Makala Wang,
Erin L. Crowgey,
Zarela MolleRios,
Zhaoping He
Publication year - 2021
Publication title -
pediatric gastroenterology, hepatology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.44
H-Index - 19
eISSN - 2234-8646
pISSN - 2234-8840
DOI - 10.5223/pghn.2021.24.5.455
Subject(s) - nonalcoholic fatty liver disease , medicine , steatosis , genotype , gastroenterology , fatty liver , obesity , biology , endocrinology , disease , genetics , gene
The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism in patatin-like phospholipase domain-containing protein 3 (PNPLA3), in nonalcoholic fatty liver disease (NAFLD). The association of these polymorphisms and NAFLD are investigated in Hispanic children with obesity.