Open AccessEffects of Carica Papaya and Psidium Guajava Extracts on Hepato-Renal Performance of Streptozotocin-Induced Diabetic Male Albino Rats
Author(s) -
Sofia Arshad,
Muhammad Ahmed Azeem,
Jawaria Muzahir,
Arifa Mehreen,
Muhammad Anwar Khan
Publication year - 2021
Publication title -
pakistan biomedical journal
Language(s) - English
Resource type - Journals
eISSN - 2709-2798
pISSN - 2709-278X
DOI - 10.52229/pbmj.v4i1.73
Subject(s) - carica , psidium , alkaline phosphatase , streptozotocin , bilirubin , creatinine , chemistry , urea , diabetes mellitus , high density lipoprotein , kidney , renal function , cholesterol , traditional medicine , enzyme , medicine , biochemistry , endocrinology , biology , botany
The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternative medicine which are relatively cheap with minimum side effects.Objective:To investigate the anti-diabetic effect of ethanolic extract of Carica papaya and Psidium guajava extracts separately and in combination, and the effect of treatment on hepato-renal performance.Methods:Papaya and guava leaves were macerated in 98% ethanol for extraction.Results:The result showed that ethanolic leaf extract of P. guajava and C. papaya significantly (P 0.05) of treated groups was observed. Serum urea and creatinine concentration was restored to normal level in treated rats with regeneration of kidney function.Conclusions:The study concluded that individual and combined plant extract show anti-hyperglycemic effect but the combined remedy at this dose show hepatotoxicity.