Open AccessIs There any Possible Role of Neurotrophin 3 in the Pathogenesis of Antrochoanal Polyp?
Author(s) -
Cengiz Özcan,
Onur İsmi,
Taylan Kara,
Gürbüz Polat,
Osman Erdoğan,
Şenay Balcı Fidancı,
Yusuf Vayısoğlu,
Kemal Görür
Publication year - 2020
Publication title -
medeniyet medical journal
Language(s) - English
Resource type - Journals
eISSN - 2149-2042
pISSN - 2149-4606
DOI - 10.5222/mmj.2020.78889
Subject(s) - pathogenesis , medicine , immunohistochemistry , pathology , concha bullosa , neurotrophin , inflammation , nasal polyps , nasal cavity , gastroenterology , surgery , paranasal sinuses , receptor
Antrochoanal polyp (ACP) is a benign soft tissue lesion arising from the inner wall of the maxillary sinus that extends into the nasal cavity and choana. Although it was first explained by Killian in 1906, the underlying pathogenesis has not been yet fully understood. Neurotrophins have been demonstrated to have a possible role in the pathogenesis of allergic rhinitis, idiopathic rhinitis and nasal polyps. To date any study has not investigated the function of neuronal inflammation and neurotrophins in the development of ACP. The objective of this study was to investigate the possible effect of neurotrophin-3 (NT-3) in ACP pathogenesis.