Open AccessAlterations of IL-1 and VEGF After Ischemia-Reperfusion Injured Uterus and Ovary in Rats
Author(s) -
Yasemin Canillioglu,
Gözde Erkanlı Şentürk
Publication year - 2020
Publication title -
medeniyet medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.128
H-Index - 4
eISSN - 2149-2042
pISSN - 2149-4606
DOI - 10.5222/mmj.2020.67026
Subject(s) - reperfusion injury , vascular endothelial growth factor , angiogenesis , ischemia , ovary , uterus , medicine , endocrinology , vegf receptors
Ischemia/reperfusion injury causes parenchymal and endothelial cell damage as a result of inflammation. Vascular endothelial growth factor (VEGF) expressed in every kind of tissue in human body has important roles in migration, proliferation, endothelial cell permeability, angiogenesis and vasculogenesis. IL-1 is a one of the cytokine family members, and plays important roles in hematopoiesis, inflammatory reactions and immune system regulation. Furthermore, auto-inflammatory diseases are treated by IL-1 as therapeutic agent. The aim of this study is to observe changes of VEGF and IL-1 immunreactivity in ischemia/reperfused rat uterus and ovary.