Open AccessCOVID-19 and Cytokine Storm
Author(s) -
Mustafa Kurtuluş,
İbrahim Pirim
Publication year - 2020
Publication title -
forbes tıp dergisi
Language(s) - English
Resource type - Journals
eISSN - 2757-5241
pISSN - 2717-9443
DOI - 10.5222/forbes.2020.79188
Subject(s) - cytokine storm , immunology , ards , cytokine , medicine , pandemic , disease , etiology , coronavirus , immune system , covid-19 , intensive care medicine , infectious disease (medical specialty) , lung , pathology
Although the etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. The word “there is no disease, there is a patient” is stil valid today. Because the immune response of the host is as important as the virulence of the pathogen in infections and disease course can vary a lot according to the person. Cytokine Storm is seen exactly in a group of diseases where the host response is very prominent. For this reason, Cytokine Storm Syndrome (CSS) is mostly mentioned. CSS emerging due to different inflammatory etiologies; it is an overwhelming systemic inflammation, hemodynamic imbalance, multiple organ failure, and potentially leading to death. After being first seen in Influenza in 2003 as a viral agent, CSS was seen in SARS-Cov, MERS-CoV and SARS-CoV2, which were found to be the las thuman disease from the Corona viridea family.The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. Uncontrolled production of pro-inammatory mediators contributes to, acut respiratory distress syndrome (ARDS) and cytokine storm syndrome in COVID-19.