Open AccessCOMPARISON BETWEEN THE EFFECTS OF EXTRACTS FROM THREE MEDICINAL PLANTS “ AMMI VISNAGA, MYRISTICA FRAGRANS AND OLEA EUROPEA” ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS.
Author(s) -
Subhanullah Jan,
Shakirullah Jan,
Muhammad Saeed Jan,
Wajid Ali,
Masud Ur Rehman
Publication year - 1969
Publication title -
journal of saidu medical college
Language(s) - English
Resource type - Journals
ISSN - 1819-4583
DOI - 10.52206/jsmc.2015.5.1.648-651
Subject(s) - ammi , myristica fragrans , olea , carbachol , traditional medicine , medicinal plants , achlorhydria , medicine , stomach , biology , botany , biochemistry , receptor , gene–environment interaction , gene , genotype
BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. Thisstudy was undertaken to find out the effects of extract from the fruits of medicinal plants Ammi visnaga,seeds of Myristica fragrans and leaves of Olea europea (all of which contain documented naturalCalcium channel blockers) on volume and acidity of Carbachol induced gastric section. Their effectswere also compared to find out any difference in their efficacy.OBJECTIVE: To find out the comparative effectiveness of three medicinal plants extracts for thetreatment of peptic ulcer and disease associated with hyper gastric acidity conditions.MATERIAL & METHODS: Forty rabbits of local breed, weighing 1-1.5kg were used. The animalswere kept on fasting for 48 hours, divided into group A, B, C & D. pylorus of each animal was ligatedafter a midline incision. Each extracts 500 mg/kg body weight and Carbachol 600pg/kg body weightwere administered in traperitoneally.RESULTS: It was found that all the extracts reduced the volume, free and total acidity of gastricsecretion, which were statistically highly significant when compared with Carbachol (PcO.OOl). Byobserving the mean values of all the extracts, it was clear that Ammi visnaga was more effective thanMyristica fragrans which was in turn more effective than Olea europea on all parameters included instudy.CONCLUSION: The three extracts therefore, can be used effectively in the treatment of peptic ulcerand all other diseases associated with hyper gastric acidity.KEY WORDS: Extracts & gastric secretion