ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

BACKGROUND: acute pancreatitis is a multisystem disease carrying broad spectrum of clinicalpresentation and complications. The objective of this study was to determine the positive role ofoctreotide in the out come of patients suffering from acute pancreatitis.OBJECTIVE: The objective of this study was to assess the role of octreotide in patients having acutepancreatitis.PATIENTS AND METHODS: This is a descriptive, comparative, prospective study. The study wasconducted in the department of surgery Saidu Group of Teaching hospital Saidu Sharif Swat fromJanuary 2011 to June 2014. Total of seventy consecutive patients having acute pancreatitis wasrandomized in a prospective trail for the treatment, at tertiary care hospital in Malakand division SwatKPK Pakistan. The data of patients were recorded on a purposely prepared proforma for this study. Thediagnosis of patients was established on basis of biochemical (serum amylase, WCC, C-reactive protein)and radiological (USG, CT- scan) investigations. The patients were divided into two groups, A and B.Group A, had received octreotide along with fluids, omeprazole, analgesic. Group B received fluids,omeprazole, analgesic without octreotide. Ages of the Group A and B were matched (±5 years). Datawas analyzed using SPSS version 16 employing chi-square test (X" test). A p-value below 0.05 wasconsidered statistically significant.RESULTS: In this prospective, comparative study two groups, each of 35 consecutive patients wereselected. The mean age in Group A was 37 ±12.41 years and in Group B 40±10.32 years (p DO.364).There were 12 males and 23 females in group A, while 14 males and 21 females in group B. Both thegroups were comparable. All the patients in octreotide group A and non-octreotide group B weresurvived. No major complications were noted in either group. As far as mean hospital stay was 7 ±2.10days in group A, while it was 9±3.14 days in group B (p<0.032). All the P- values for the criteria ofstudy were calculated. P-values were significant when we consider pain control and hospital stay intwo groups.CONCLUSION: In our study we found that octreotide was more effective in the final outcome ofpatients with acute pancreatitis. There is clear cut beneficial effect of octreotide on hospital stay andreduced need of analgesics in patients having acute pancreatitis.KEYWORDS: Acute Pancreatitis, Octreotide, Hospital Stay, pain control.