Open AccessTHYROXINE PRESERVES THE ARCHITECTURE OF PANCREATIC ISLETS OF LANGERHANS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Author(s) -
Mariyah Hidayat,
Inayatullah,
Yasmeen Mahar,
Mohammad Firoz Khan
Publication year - 1969
Publication title -
journal of saidu medical college
Language(s) - English
Resource type - Journals
ISSN - 1819-4583
DOI - 10.52206/jsmc.2015.5.1.586-590
Subject(s) - streptozotocin , medicine , diabetes mellitus , endocrinology , islet , pancreas , endocrine system , pancreatic islets , body weight , hormone
BACKGROUND: In experimental animal models, Streptozotocin (STZ) induced diabetes, causesdisruption of the normal architecture of the islets of Langerhans and exogenous administration ofthyroxine in diabetic rats preserves the anatomy of endocrine pancreas.OBJECTIVE: This study was performed to observe the effect of thyroxine on the pancreas of albinorats during STZ induced diabetes.MATERIAL AND METHODS: This is a Prospective experimental study was conducted in Anatomydepartment at BMSI, JPMC, Karachi from 01 November to 15 December 2013. In this study sixtyhealthy adult albino rats were included in the study and divided equally into 3 groups for 6 weeks.Group-A was taken as control. Group-B received STZ (I/P) in a dose of 37 mg/kg body weight. GroupC received STZ in the same dose and additionally received thyroxine (1 mg/kg (s.c.) thrice a week for 6weeks.RESULTS: STZ significantly increased serum glucose level and decreased weight in group B animals,whereas in group C, thyroxine significantly restored serum glucose level but could not restore the bodyweights reduced by streptozotocin. Moreover, thyroxine significantly preserved the morphology ofpancreatic islets in group C animals.CONCLUSION: Thyroxine restores the structure of pancreatic islets distorted by STZ and reduceshyperglycemia, but cannot restore the body weight.KEYWORDS: Streptozotocin, Thyroxine, Diabetes Mellitus, Hyperglycaemia, islets of Langerhans, Albino rats.